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Profiling the Cell Surface Landscape of Proteasome Inhibitor-Treated and -Resistant Multiple Myeloma to Guide Immunotherapy Targeting, Diagnosis, and Biology.

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Ian Ferguson, Yu-Hsiu T. Lin, Sami Tuomivaara, Jeffrey L. Wolf, Thomas G. Martin, Sandy W. Wong, Nina D. Shah, Christoph Driessen, Brian G. Van Ness, Arun P. Wiita

In Vitro-Selected Nanobody-Based Cellular Therapy Targeting CD72 for Treatment of Refractory B-Cell Malignancies.

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Matthew Nix, Yu-Hsiu T. Lin, Huimin Geng, Makeba Marcoulis, Paul Phojanakong, Donghui Wang, Veronica Steri, Jeffrey Whitman, Sagar Bapat, Elliot Stieglitz, Anne Deucher, Kristie L White, Byron C Hann, Arun P. Wiita

Ifitm3 Is Essential for PI(3,4,5)P3-Dependent B-Cell Activation and Leukemogenesis.

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Jaewoong Lee, Gang Xiao, Kadriye Nehir Nehir Cosgun, Huimin Geng, Ning Ma, Lai N Chan, Kohei Kume, Matthew Nix, Zhengshan Chen, Chun-Wei David Chen, Jianjun Chen, Vishal Khairnar, Arun P. Wiita, Andrei Thomas-Tikhonenko, Michael Farzan, Michael S. Diamond, Jae U Jung, Nagarajan Vaidehi, Markus Müschen

Novel Allosteric Inhibitors of Heat Shock Protein 70 As Agents to Probe Protein Homeostasis and Overcome Proteasome Inhibitor Resistance in Multiple Myeloma.

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Ian Ferguson, Christine Lam, Margarette C. Mariano, Donghui Wang, Paul Phojanakong, Sami Toumivaara, Hao Shao, Byron C Hann, Jason Gestwicki, Arun P Wiita

Integrating Phosphoproteomics and Transcriptional Classifiers Reveals "Hidden Signaling" in Multiple Myeloma Including Differential KRAS and NRAS Mutant Effects.

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Yu-Hsiu T. Lin, Gergory P. Way, Margarette C. Mariano, Makeba Marcoulis, Ian Ferguson, Casey S. Greene, Arun P Wiita

Identifying Factors in Multiple Myeloma Controlling Response to B-Cell Maturation Antigen (BCMA)-Targeted Immunotherapy Using CRISPR-Based Functional Genomics.

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Poornima Ramkumar, Jaime Leong, Meghan Seyler, Stratton J Georgoulis, Axel Hyrenius Wittsten, Priya Choudhry, Kole Roybal, Arun P Wiita, Martin Kampmann

IFITM3-Mediated Regulation of Cell Membrane Dynamics Is Essential for Malignant B-Cell Transformation.

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Jae-Woong Lee, Huimin Geng, Derek S Dinson, Gang Xiao, Kadriye Nehir Cosgun, Lai N Chan, Zhengshan Chen, Michael Farzan, Jae U Jung, Arun P Wiita, Markus Muschen

Tofacitinib Reverses Growth Promoting Effects of the Bone Marrow Stromal Environment Though Inhibition of JAK1/STAT3 Signaling in Multiple Myeloma.

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Christine Lam, Megan Murnane, Geoffrey A. Smith, Jack Taunton, Blake T. Aftab, Arun P. Wiita

CD46 Is Amplified in High-Risk Myeloma with Gain of Chromosome 1q and Selectively Targeted By a Novel Anti-CD46 Antibody-Drug Conjugate.

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Daniel W. Sherbenou, Blake T. Aftab, Yang Su, Christopher R. Behrens, Arun P. Wiita, Aaron C. Logan, Diego Acosta-Alvear, Byron C. Hann, Peter Walter, Xiaobo Wu, John P. Atkinson, Jeffrey L. Wolf, Thomas G. Martin, Bin Liu

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