Check Out Our Progress Through Our Publications!
Click on a Year to Jump to Publications
Preprints | 2015 and earlier | 2016 | 2017 | 2018 | 2019 | 2020 | 2021 | 2022 | 2023 | 2024 | 2025
Preprints and Abstracts
Abstract 4820: Anti-CD72 nanobody-based CAR-T affinity maturation leads to improved in vitro efficacy versus low antigen density lymphoma models, but limited benefit in vivo. Cancer Research. 2025 Apr 21; 85(8_Supplement_1):4820-4820. Izgutdina IA, Rashid RT, Patino-Escobar PB, Walunj WS, Geng GH, Kang KA, Chen CS, Johnson JH, Temple TW, Nix NM, Naik NA, Ramos RE, Takamatsu TH, Gil-Alós GD, Martinez-Lopez MJ, Valeri VA, Yuan YC, Wang WH, Aminov AS, Sahu SS, Carpenter CC, Salangsang SF, Phojanakong PP, Camara Serrano CJ, Tariq TI, Steri SV, Parekh PS, Verma VA, Shah SN, Wiita WA.
Development of a Dual-Antigen Targeting CAR-T Therapy Directed Against CD70 and Active Integrin ß2 for Acute Myeloid Leukemia. Blood. 2024 Nov 5; 144(Supplement 1):2037-2037. Kang KA, Johnson JH, Razi RN, Lei LN, Logan LA, Huang HB, Wiita WA. .
Histologic variants in bladder cancer harbor aggressive molecular features including TM4SF1 expression and a CA125+ cell state Heiko Yang, Hanbing Song, Elizabeth Yip, Kevin Chang, Paul Allegakoen, Kevin Lu, Keliana Hui, Julia Pham, Corynn Kasap, Vipul Kumar, Janae Gayle, Bradley A. Stohr, Chien-Kuang Cornelia Ding, Arun P. Wiita, Maxwell V. Meng, Jonathan Chou, Sima P. Porten, Franklin W. Huang. bioRxiv, 2024.05.20.595039; DOI: https://doi.org/10.1101/2024.05.20.595039
Tumor-wide RNA splicing aberrations generate immunogenic public neoantigensDarwin W. Kwok, Nicholas O. Stevers, Takahide Nejo, Lee H. Chen, Inaki Etxeberria, Jangham Jung, Kaori Okada, Maggie Colton Cove, Senthilnath Lakshmanachetty, Marco Gallus, Abhilash Barpanda, Chibo Hong, Gary K.L. Chan, SamuelH. Wu, Emilio Ramos, Akane Yamamichi, Jerry Liu, Payal Watchmaker, Hirokazu Ogino, Atsuro Saijo, Aidan Du, Nadia Grishanina, James Woo, Aaron Diaz, Susan M. Chang, Joanna J. Phillips, Arun P. Wiita, Christopher A. Klebanoff, Joseph F. Costello, Hideho Okada bioRxiv 2023.10.19.563178; doi: https://doi.org/10.1101/2023.10.19.563178
2025
Targeting high-risk multiple myeloma genotypes with optimized anti-CD70 CAR-T cells. Blood. 2025 May 13. Kasap C, Izgutdina A, Patiño-Escobar B, Kang AS, Chilakapati N, Akagi N, Manoj AM, Johnson H, Rashid T, Werner J, Barpanda A, Geng H, Lin YT, Rampersaud S, Gil-Alós D, Sobh A, Dupéré-Richer D, Aleman A, Wicaksono G, Kelii KMK, Dalal R, Ramos E, Vijayanarayanan A, Lakhani K, Salangsang F, Phojanakong P, Camara Serrano JA, Zakraoui O, Tariq I, Chari A, Chung A, Kumar AD, Martin T, Wolf JL, Wong S, Steri V, Shanmugam M, Boise LH, Kortemme T, Parekh S, Stieglitz E, Licht JD, Karlon W, Barwick BG, Wiita A. PMID: 40359480.
Cellular immunotherapy targeting CLL-1 for juvenile myelomonocytic leukemia. Nat Commun. 2025 Apr 23; 16(1):3804. Werner J, Lee AG, Zhang C, Abelson S, Xirenayi S, Rivera J, Yousuf K, Shin H, Patiño-Escobar B, Bachl S, Mandal K, Barpanda A, Ramos E, Izgutdina A, Chaudhuri S, Temple WC, Bhatnagar S, Dardis JK, Meyer J, Morales C, Meshinchi S, Loh ML, Braun B, Tasian SK, Wiita AP, Stieglitz E. PMID: 40268927; PMCID: PMC12019388.
Technology Spotlight Surface Target Discovery for Blood Cancer Immunotherapies. The Hematologist. 2025 Jan 9; 22(1). Patiño-Escobar PB, Perez-Lugo PL, Wiita WA.
2024
HLA-Pan-DP CAR-T Demonstrates Cytotoxicity Against Multiple Hematological Malignancies. Blood. 2024 Nov 5; 144(Supplement 1):1038-1038. Takamatsu TH, Ramos RE, Patino-Escobar PB, Kasap KC, Izgutdina IA, Werner WJ, Inagaki IA, Yoroidaka YT, Salangsang SF, Phojanakong PP, Camara Serrano CJ, Steri SV, Stieglitz SE, Nagato NM, Tatsuno TS, Wiita WA. .
Novel Single-Cell RNA Technology Simplifies Measurement of Anti-BCMA CAR-Ts in Patient Samples. Blood. 2024 Nov 5; 144(Supplement 1):4978-4978. Chen CS, Cienciala CM, Rashid RT, Patino Escobar PB, Berne BL, Georgiev GD, Wiita WA.
Mitochondrial Priming Is Heterogenous in t(4;14) Multiple Myeloma and Can be Induced By Inhibition of NSD2. Blood. 2024 Nov 5; 144(Supplement 1):4663-4663. Matulis MS, Chavez CR, Owens OR, Wiita WA, Shanmugam SM, De Matos Simoes DR, Mitsiades MC, Joseph JN, Hofmeister HC, Kaufman KJ, Dhodapkar DM, Lonial LS, Nooka NA, Gupta GV, Licht LJ, Barwick BB, Boise BL. .
CD48: Friend or Foe in NK-Cell Immunosurveillance of Multiple Myeloma? Blood. 2024 Nov 5; 144(Supplement 1):4646-4646. Patiño-Escobar PB, Perez-Lugo PL, Geng GH, Salangsang SF, Phojanakong PP, Camara Serrano CJ, Steri SV, Aguilar AO, Wiita WA. .
Structure Guided Design of CCL27 CAR T-Cells Against CCR10 for Multiple Myeloma. Blood. 2024 Nov 5; 144(Supplement 1):2036-2036. Chilakapati CN, Patino-Escobar PB, deMontagnac dJ, Johnson JH, Ramos RE, Phojanakong PP, Salangsang SF, Steri SV, Karlon KW, Wiita WA. .
A multi-subunit autophagic capture complex facilitates degradation of ER stalled MHC-I in pancreatic cancer. bioRxiv. 2024 Oct 29. Berquez M, Li AL, Luy MA, Venida AC, O'Loughlin T, Rademaker G, Barpanda A, Hu J, Yano J, Wiita A, Gilbert LA, Bruno PM, Perera RM. PMID: 39554122; PMCID: PMC11565957
SLAPSHOT reveals rapid dynamics of extracellularly exposed proteome in response to calcium-activated plasma membrane phospholipid scrambling.Tuomivaara ST*, Teo CF*, Jan YN, Wiita AP^, Jan LY^. Communications Biology [accepted] (2024). (*co-first author; ^co-corresponding author)
Functional multi-omics reveals genetic and pharmacologic regulation of surface CD38 in multiple myeloma. Choudhry P, Gugliemini O, Geng H, Sarin V, Sarah L, Lin Y-HT, Paranjape N, Ramkumar P, Marcoulis M, Wang D, Phojanakong P, Steri V, Hann B, Kampmann M, Wiita AP. Blood Neoplasia [in press] (2024)
Cell-Type Specificity of Mosaic Chromosome 1q Gain Resolved by snRNA-seq in a Case of Epilepsy With Hyaline Protoplasmic Astrocytopathy Kun Leng, PhD, Cathryn R. Cadwell, MD, PhD, Walter P. Devine, MD, PhD, Tarik Tihan, MD, PhD, Zhongxia Qi, PhD, Nilika S. Singhal, MD, Orit A. Glenn, MD, Sherry Kamiya, BS, Arun P. Wiita, MD, PhD, Amy C. Berger, MD, PhD, Joseph T. Shieh, MD, PhD, Erron W. Titus, MD, PhD, Mercedes F. Paredes, MD, PhD, and Vaibhav Upadhyay, MD, PhD. Neurology Genetics 2024;10:e200142. DOI:10.1212/NXG.0000000000200142
Challenges in the discovery of tumor-specific alternative splicing-derived cell-surface antigens in glioma. Takahide Nejo, Lin Wang, Kevin K. Leung, Albert Wang, Senthilnath Lakshmanachetty, Marco Gallus, Darwin W. Kwok, Chibo Hong, Lee H. Chen, Diego A. Carrera, Michael Y. Zhang, Nicholas O. Stevers, Gabriella C. Maldonado, Akane Yamamichi, Payal B. Watchmaker, Akul Naik, Anny Shai, Joanna J. Phillips, Susan M. Chang, Arun P. Wiita, James A. Wells, Joseph F. Costello, Aaron A. Diaz & Hideho Okada. Sci Rep 14, 6362 (2024). DOI: https://doi.org/10.1038/s41598-024-56684-0
Thalamocortical organoids enable in vitro modeling of 22q11.2 microdeletion associated with neuropsychiatric disorders. Shin D, Kim CN, Ross J, Hennick KM, Wu SR, Paranjape N, Leonard R, Wang JC, Keefe MG, Pavlovic BJ, Donohue KC, Moreau C, Wigdor EM, Larson HH, Allen DE, Cadwell CR, Bhaduri A, Popova G, Bearden CE, Pollen AA, Jacquemont S, Sanders SJ, Haussler D, Wiita AP, Frost NA, Sohal VS, Nowakowski TJ. Cell Stem Cell. 2024 Mar 7;31(3):421-432.e8. Epub 2024 Feb 20. PMID: 38382530 DOI: 10.1016/j.stem.2024.01.010.
Alternative target recognition elements for chimeric antigen receptor (CAR) T cells: beyond standard antibody fragments, Matthew A. Nix, Arun P. Wiita. Cytotherapy, 2024, DOI: https://doi.org/10.1016/j.jcyt.2024.02.024.
CD46-Targeted Theranostics for PET and 225Ac-Radiopharmaceutical Therapy of Multiple Myeloma. Anju Wadhwa, Sinan Wang, Bonell Patiño-Escobar, Anil P. Bidkar, Kondapa Naidu Bobba, Emily Chan, Niranjan Meher, Scott Bidlingmaier, Yang Su, Suchi Dhrona, Huimin Geng, Vishesh Sarin, Henry F. VanBrocklin, David M. Wilson, Jiang He, Li Zhang, Veronica Steri, Sandy W. Wong, Thomas G. Martin, Youngho Seo, Bin Liu, Arun P. Wiita, Robert R. Flavell. Clin Cancer Res 1 March 2024; 30 (5): 1009–1021. https://doi.org/10.1158/1078-0432.CCR-23-2130
2023
Structural surfaceomics reveals an AML-specific conformation of integrin β2 as a CAR T cellular therapy target. Kamal Mandal, Gianina Wicaksono, Clinton Yu, Jarrett J. Adams, Michael R. Hoopmann, William C. Temple, Adila Izgutdina, Bonell Patiño Escobar, Maryna Gorelik, Christian H. Ihling, Matthew A. Nix, Akul Naik, William H. Xie, Juwita Hübner, Lisa A. Rollins, Sandy M. Reid, Emilio Ramos, Corynn Kasap, Veronica Steri, Juan Antonio Camara Serrano, Fernando Salangsang, Paul Phojanakong, Melanie McMillan, Victor Gavallos, Andrew D. Leavitt, Aaron C. Logan, Cliona M. Rooney, Justin Eyquem, Andrea Sinz, Benjamin J. Huang, Elliot Stieglitz, Catherine C. Smith, Robert L. Moritz, Sachdev S. Sidhu, Lan Huang & Arun P. Wiita. Nature Cancer 4, 1592–1609 (2023). DOI: https://doi.org/10.1038/s43018-023-00652-6
Transcriptional repression upon S phase entry protects genome integrity in pluripotent cells. Deniz Gökbuget, Kayla Lenshoek, Ryan M. Boileau, Jonathan Bayerl, Hector Huang, Arun P. Wiita, Diana J. Laird & Robert Blelloch. Nat Struct Mol Biol 30, 1561–1570 (2023). DOI: https://doi.org/10.1038/s41594-023-01092-7
Overcoming Proteasome Inhibitor Resistance in the Immunotherapy Era. Bonell Patiño-Escobar, Alexis Talbot, Arun P. Wiita. Trends in Pharmacological Sciences (44) 507 - 518 (2023). DOI:https://doi.org/10.1016/j.tips.2023.05.006
Cytomegalovirus seropositivity is associated with improved responses to CD38 monoclonal antibody therapies in multiple myeloma: A single-centre retrospective study. Alex Y. Ge, Chiung-Yu Huang, Rahul Banerjee, Jennifer Knoche, Alfred Chung, Shagun Arora, Thomas G. Martin, Jeffrey Wolf, Sandy W. Wong, Arun P. Wiita, Nina Shah. Br J Haematol. 2023; 201(5): 935–939. https://doi.org/10.1111/bjh.18711
A CRISPR-engineered isogenic model of the 22q11.2 A-B syndromic deletion. Neha Paranjape, Yu-Hsiu T. Lin, Quetzal Flores-Ramirez, Vishesh Sarin, Amanda Brooke Johnson, Julia Chu, Mercedes Paredes* & Arun P. Wiita*. Sci Rep 13, 7689 (2023). https://doi.org/10.1038/s41598-023-34325-2. (*co-corresponding)
Framework humanization optimizes potency of anti-CD72 nanobody CAR-T cells for B-cell malignancies. Temple WC, Nix MA, Naik A, Izgutdina A, Huang BJ, Wicaksono G, Phojanakong P, Serrano JAC, Young EP, Ramos E, Salangsang F, Steri V, Xirenayi S, Hermiston M, Logan AC, Stieglitz E, Wiita AP. J Immunother Cancer. 2023 Nov 24;11(11):e006985. doi: 10.1136/jitc-2023-006985.
2022
Unraveling the surface proteomic profile of multiple myeloma to reveal new immunotherapeutic targets and markers of drug resistance. Patiño-Escobar B, Ferguson ID, Wiita AP. . Cell Stress. 2022 Oct 13;6(11):89-92. doi: 10.15698/cst2022.11.273.
Therapeutic implications of mitochondrial stress-induced proteasome inhibitor resistance in multiple myeloma. Sharma A, Nair R, Achreja A, Mittal A, Gupta P, Balakrishnan K, Edgar CL, Animasahun O, Dwivedi B, Barwick BG, Gupta VA, Matulis SM, Bhasin M, Lonial S, Nooka AK, Wiita AP, Boise LH, Nagrath D, Shanmugam M. Sci Adv. 2022 Sep 30;8(39):eabq5575. doi: 10.1126/sciadv.abq5575.
ECM dimensionality tunes actin tension to modulate endoplasmic reticulum function and spheroid phenotypes of mammary epithelial cells. Kai F, Ou G, Tourdot RW, Stashko C, Gaietta G, Swift MF, Volkmann N, Long AF, Han Y, Huang HH, Northey JJ, Leidal AM, Viasnoff V, Bryant DM, Guo W, Wiita AP, Guo M, Dumont S, Hanein D, Radhakrishnan R, Weaver VM. EMBO J. 2022 Sep 1;41(17):e109205. doi: 10.15252/embj.2021109205.
Allosteric HSP70 inhibitors perturb mitochondrial proteostasis and overcome proteasome inhibitor resistance in multiple myeloma. Ferguson ID, Lin YT, Lam C, Shao H, Tharp KM, Hale M, Kasap C, Mariano MC, Kishishita A, Patiño Escobar B, Mandal K, Steri V, Wang D, Phojanakong P, Tuomivaara ST, Hann B, Driessen C, Van Ness B, Gestwicki JE, Wiita AP. Cell Chem Biol. 2022 Aug 18;29(8):1288-1302.e7. doi: 10.1016/j.chembiol.2022.06.010.
The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance. Ferguson ID, Patiño-Escobar B, Tuomivaara ST, Lin YT, Nix MA, Leung KK, Kasap C, Ramos E, Nieves Vasquez W, Talbot A, Hale M, Naik A, Kishishita A, Choudhry P, Lopez-Girona A, Miao W, Wong SW, Wolf JL, Martin TG 3rd, Shah N, Vandenberg S, Prakash S, Besse L, Driessen C, Posey AD Jr, Mullins RD, Eyquem J, Wells JA, Wiita AP. Nat Commun. 2022 Jul 15;13(1):4121. doi: 10.1038/s41467-022-31810-6. View Open Access article at Nature Communications
Secretory autophagy maintains proteostasis upon lysosome inhibition. Solvik TA, Nguyen TA, Tony Lin YH, Marsh T, Huang EJ, Wiita AP, Debnath J, Leidal AM. J Cell Biol. 2022 Jun 6;221(6):e202110151. doi: 10.1083/jcb.202110151.
2021
GRASP55 restricts early-stage autophagy and regulates spatial organization of the early secretory network. Liu JY, Lin YT, Leidal AM, Huang HH, Ye J, Wiita AP, Debnath J. Biol Open (2021) 10(10):bio058736. View open access article at Biology Open.
FceR1g negative (g-NK) cells persist in vivo and enhance efficacy of therapeutic monoclonal antibodies in multiple myeloma. Bigley, A.B.*, Spade, S., Agha, N.H., Biswas, S., Tang, S., Malik, M.H., Dai, L., Masoumi, S., Patino Escobar, B., Hale, M., DiPierro, G., Martell, R., Hann, B., Shah, N., Wiita, A.P.*, and Liu, X*.Blood Adv (2021), 5:3021. (* = co-corresponding). View open access article at Blood Advances.
Surface proteomics reveals CD72 as a target for in vitro-evolved nanobody-based CAR-T cells in KMT2A/MLL1-rearranged B-ALL. Nix, M.A., Mandal, K., Geng, H., Paranjape, N., Lin, YH, Rivera, J., Marcoulis, M., White, K.L., Whitman, J.D., Bapat, S.P., Parker, K.R., Ramirez, J., Deucher, A., Phojanokong, P., Steri, V., Fattahi, F., Hann, B., Satpathy, A.T., Manglik, A., Stieglitz, E., and Wiita, A.P. Cancer Discovery (2021) 11:2032 View at Pubmed
2020
A guide to using ClinTAD for interpretation of DNA copy number variants in the context of topologically associated domains. Spector JD, Wiita AP. Curr Protoc Hum Genet (2020). doi: 10.1002/cphg.106. View at Pubmed
IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells. Lee J, Robinson ME, Ma N, Artadji D, Ahmed MA, Xiao G, Sadras T, Deb G, Winchester J, Cosgun KN, Geng H, Chan LN, Kume K, Miettinen TP, Zhang Y, Nix MA, Klemm L, Chen CW, Chen J, Khairnar V, Wiita AP, Thomas-Tikhonenko A, Farzan M, Jung JU, Weinstock DM, Manalis SR, Diamond MS, Vaidehi N, Müschen M. Nature (2020) 588:491. View at Pubmed.
Engineered ACE2 receptor traps potently neutralize SARS-CoV-2. Glasgow A, Glasgow J, Limonta D, Solomon P, Lui I, Zhang Y, Nix MA, Rettko NJ, Lim SA, Zha S, Yamin R, Kao K, Rosenberg OS, Ravetch JV, Wiita AP, Leung KK, Zhou XX, Hobman TC, Kortemme T, Wells JA. Proc Natl Acad Sci USA (2020) 117:28046. View open access article at PNAS
Signalling input from divergent pathways subverts B cell transformation. Chan LN, Murakami MA, Robinson ME, Caeser R, Sadras T, Lee J, Cosgun KN, Kume K, Khairnar V, Xiao G, Ahmed MA, Aghania E, Deb G, Hurtz C, Shojaee S, Hong C, Pölönen P, Nix MA, Chen Z, Chen CW, Chen J, Vogt A, Heinäniemi M, Lohi O, Wiita AP, Izraeli S, Geng H, Weinstock DM, Müschen M. Nature (2020) 583:845. View at Pubmed.
CRISPR-based screens uncover determinants of immunotherapy response in multiple myeloma. Ramkumar P, Abarientos AB, Tian R, Seyler M, Leong JT, Chen M, Choudhry P, Hechler T, Shah N, Wong SW, Martin TG, Wolf JL, Roybal KT, Pahl A, Taunton J, Wiita AP, Kampmann M. Blood Adv (2020) 4:2899. View open access article at Blood Advances
Proteasome inhibitor-induced modulation reveals the spliceosome as a specific therapeutic vulnerability in multiple myeloma. Huang HH, Ferguson ID, Thornton AM, Bastola P, Lam C, Lin YT, Choudhry P, Mariano MC, Marcoulis MD, Teo CF, Malato J, Phojanakong PJ, Martin TG 3rd, Wolf JL, Wong SW, Shah N, Hann B, Brooks AN, Wiita AP. Nat Commun. (2020) 11:1931. View open access article at Nature Communications
Lessons Learned from Proteasome Inhibitors, the Paradigm for Targeting Protein Homeostasis in Cancer. Kambhampati S, Wiita AP. Adv Exp Med Biol. (2020) 1243:147. View at Pubmed
Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway. Guo X, Aviles G, Liu Y, Tian R, Unger BA, Lin YT, Wiita AP, Xu K, Correia MA, Kampmann M. Nature (2020) 579:427. View free full text at Pubmed Central
valuating the efficacy of multiple myeloma cell lines as models for patient tumors via transcriptomic correlation analysis. Sarin V, Yu K, Ferguson ID, Gugliemini O, Nix MA, Hann B, Sirota M, Wiita AP. E Leukemia (2020) 34:2754. View free full text at Pubmed Central
The LC3-conjugation machinery specifies the loading of RNA-binding proteins into extracellular vesicles. Leidal AM, Huang HH, Marsh T, Solvik T, Zhang D, Ye J, Kai F, Goldsmith J, Liu JY, Huang YH, Monkkonen T, Vlahakis A, Huang EJ, Goodarzi H, Yu L, Wiita AP, Debnath J. Nat Cell Biol. (2020) 22:187. View free full text at Pubmed Central
DNA methyltransferase inhibitors upregulate CD38 protein expression and enhance daratumumab efficacy in multiple myeloma. Choudhry P, Mariano MC, Geng H, Martin TG 3rd, Wolf JL, Wong SW, Shah N, Wiita AP. Leukemia. (2020) 34:938. View open access article at Leukemia
2019
Integrated Phosphoproteomics and Transcriptional Classifiers Reveal Hidden RAS Signaling Dynamics in Multiple Myeloma. Lin Y-H, Way GP, Barwick BG, Mariano MC, Marcoulis M, Ferguson ID, Driessen C, Boise LH, Greene CS, Wiita AP. Blood Adv (2019) 3:3214. View open access article at Blood Advances. View preprint at BioRxiv
TMEM16A controls EGF-induced calcium signaling implicated in pancreatic cancer prognosis. Crottès D, Lin YT, Peters CJ, Gilchrist JM, Wiita AP, Jan YN, Jan LY. Proc Natl Acad Sci USA (2019) 116:13026. View on Pubmed
ClinTAD: a tool for copy number variant interpretation in the context of topologically associated domains. Spector JD, Wiita AP. J Hum Genet (2019) 64:437. View on Pubmed
Efficient tumor killing and minimal cytokine release with novel T-cell agonist bispecific antibodies. Trinklein ND, Pham D, Schellenberger U, Buelow B, Boudreau A, Choudhry P, Clarke SC, Dang K, Harris KE, Iyer S, Jorgensen B, Pratap PP, Rangaswamy US, Ugamraj HS, Vafa O, Wiita AP, van Schooten W, Buelow R, Force Aldred S. mAbs (2019) 11:639. View on Pubmed
2018
Targeting CD74 in multiple myeloma with the novel, site-specific antibody-drug conjugate STRO-001. Abrahams CL, Li X, Embry M, Yu A, Krimm S, Krueger S, Greenland NY, Wen KW, Jones C, DeAlmeida V, Solis WA, Matheny S, Kline T, Yam AY, Stafford R, Wiita AP, Hallam T, Lupher M, Molina A. Oncotarget (2018) 9:37700. View on Pubmed
Seeking Convergence and Cure with New Myeloma Therapies. Choudhry P, Galligan D, Wiita AP. Trends Cancer (2018) 4:567. View on Pubmed
Repurposing tofacitinib as an anti-myeloma therapeutic to reverse growth-promoting effects of the bone marrow microenvironment. Lam C, Ferguson ID, Mariano MC, Lin YT, Murnane M, Liu H, Smith GA, Wong SW, Taunton J, Liu JO, Mitsiades CS, Hann BC, Aftab BT, Wiita AP. Haematologica (2018) 103:1218. View on Pubmed
A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle. Goode B, Mondal G, Hyun M, Ruiz DG, Lin, Y-H, Van Ziffle J, Joseph NM, Onodera C, Talevich E, Grenert JP, Hewedi IH, Snuderl M, Brat DJ, Kleinschmidt-DeMasters BK, Rodriguez FJ, Louis DN, Yong WH, Lopes MB, Rosenblum MK, Butowski N, Tihan T, Bollen AW, Phillips JJ, Wiita AP, Yeh I, Jacobsen MP, Bastian BC, Perry A, Solomon DA. Nat Comm (2018) 9:810. View on Pubmed
2017
Cellular phenotypes in human iPSC-derived neurons from a genetic model of autism spectrum disorder. Deshpande A, Yadav S, Dao DQ, Wu Zhi-Yong, Hokanson KC, Cahill MK, Wiita AP, Jan Y-N, Ullian EM, Weiss LA. Cell Rep (2017) 21:2678. View on Pubmed
The p97 inhibitor CB-5083 is a unique disrupter of protein homeostasis in models of multiple myeloma. Le Moigne R, Aftab Bt, Djakovic S, Dhimolea E, Valle E, Murnane M, King EM, Soriano F, Menon MK, Wu ZY, Wong ST, Lee GJ, Yao B, Wiita AP, Lam C, Rice J, Wang J, Chesi M, Bergsagel PL, Kraus M, Driessen C, Kiss von Soly S, Yakes FM, Wustrow D, Shawver L, Zhou HJ, Martin TG, Wolf JL, Mitsiades CS, Anderson DJ, Rolfe M. Mol Cancer Ther (2017) 16:2375. View on Pubmed
Time-resolved proteomics extends ribosome profiling-based measurements of protein synthesis dynamics. Liu T-Y*, Huang HH*, Wheeler D, Xu Y, Wells JA, Song YS+, Wiita AP+. Cell Systems (2017) 4:636. View on Pubmed
(*=co-first author; +=co-corresponding)
False negative fetal cell free DNA screening for microdeletion syndromes in the presence of an unbalanced translocation involving monosomy 4p. Qi Z, Madaan S, Chetty S, Yu J, Wiita AP. Prenat Diagn (2017) 37:420.
View on Pubmed
2016
Antibody-drug conjugate targeting CD46 eliminates multiple myeloma cells. Sherbenou DW, Aftab BT, Su Y, Behrens CR, Wiita A, Logan AC, Acosta-Alvear D, Hann BC, Walter P, Shuman MA, Wu X, Atkinson JP, Wolf JL, Martin TG, Liu B. J Clin Invest (2016) 126:4640.
View on Pubmed
Phosphorylation of Beta-tubulin by the Down syndrome kinase, Minibrain/DYRK1a, regulates microtubule dynamics and dendrite morphogenesis. Ori-McKenney KM, McKenney RJ, Huang HH, Li T, Meltzer S, Jan LY, Vale RD, Wiita AP, Jan YN. Neuron (2016) 90:551.
View on Pubmed
False positive cell free DNA screening for microdeletions due to non-pathogenic copy number variants. Mather CA, Qi Z, Wiita AP. Prenat Diagn (2016) 36:584
View on Pubmed
Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles. Julien O, Zhuang M, Wiita AP, O'Donoghue AJ, Knudsen GM, Craik CS, Wells JA. Proc Natl Acad Sci USA (2016) 113:E2001
View on Pubmed
2015 and earlier
Circulating proteolytic signatures of chemotherapy-induced cell death in humans discovered by N-terminal labeling. Wiita AP, Hsu GW, Lu CM, Esensten JH, Wells JA. Proc Natl Acad Sci U S A. 2014 May 27; 111(21):7594-9.
View on PubMed
Targeted Peptide Measurements in Biology and Medicine: Best Practices for Mass Spectrometry-based Assay Development Using a Fit-for-Purpose Approach. Carr SA, Abbatiello SE, Ackermann BL, Borchers C, Domon B, Deutsch EW, Grant RP, Hoofnagle AN, Hüttenhain R, Koomen JM, Liebler DC, Liu T, Maclean B, Mani D, Mansfield E, Neubert H, Paulovich AG, Reiter L, Vitek O, Aebersold R, Anderson L, Bethem R, Blonder J, Boja E, Botelho J, Boyne M, Bradshaw RA, Burlingame AL, Chan D, Keshishian H, Kuhn E, Kinsinger C, Lee JS, Lee SW, Moritz R, Oses-Prieto J, Rifai N, Ritchie J, Rodriguez H, Srinivas PR, Townsend RR, Van Eyk J, Whiteley G, Wiita A, Weintraub S. Mol Cell Proteomics. 2014 Mar; 13(3):907-17.
View on PubMed
Global analysis of cellular proteolysis by selective enzymatic labeling of protein N-termini. Methods Enzymol. Wiita AP, Seaman JE, Wells JA. 2014; 544:327-58.
View on PubMed
Global cellular response to chemotherapy-induced apoptosis. Wiita AP, Ziv E, Wiita PJ, Urisman A, Julien O, Burlingame AL, Weissman JS, Wells JA. Elife. 2013; 2:e01236.
View on PubMed
Longitudinal management with crossmatch-compatible platelets for refractory patients: alloimmunization, response to transfusion, and clinical outcomes (CME). Wiita AP, Nambiar A. Transfusion. 2012 Oct; 52(10):2146-54.
View on PubMed
Cytomegalovirus disease and infection in lung transplant recipients in the setting of planned indefinite valganciclovir prophylaxis. Wiita AP, Roubinian N, Khan Y, Chin-Hong PV, Singer JP, Golden JA, Miller S. Transpl Infect Dis. 2012 Jun; 14(3):248-58.
View on PubMed
Clinical application of high throughput molecular screening techniques for pharmacogenomics. Wiita AP, Schrijver I. Pharmgenomics Pers Med. 2011; 4:109-21.
View on PubMed
Diversity of chemical mechanisms in thioredoxin catalysis revealed by single-molecule force spectroscopy. Perez-Jimenez R, Li J, Kosuri P, Sanchez-Romero I, Wiita AP, Rodriguez-Larrea D, Chueca A, Holmgren A, Miranda-Vizuete A, Becker K, Cho SH, Beckwith J, Gelhaye E, Jacquot JP, Gaucher EA, Gaucher E, Sanchez-Ruiz JM, Berne BJ, Fernandez JM. Nat Struct Mol Biol. 2009 Aug; 16(8):890-6.
View on PubMed
Force-clamp spectroscopy detects residue co-evolution in enzyme catalysis. Perez-Jimenez R, Wiita AP, Rodriguez-Larrea D, Kosuri P, Gavira JA, Sanchez-Ruiz JM, Fernandez JM. J Biol Chem. 2008 Oct 3; 283(40):27121-9.
View on PubMed
Single-molecule force spectroscopy measurements of bond elongation during a bimolecular reaction. Koti Ainavarapu SR, Wiita AP, Dougan L, Uggerud E, Fernandez JM. J Am Chem Soc. 2008 May 21; 130(20):6479-87.
View on PubMed
A single-molecule assay to directly identify solvent-accessible disulfide bonds and probe their effect on protein folding. Ainavarapu SR, Wiita AP, Huang HH, Fernandez JM. J Am Chem Soc. 2008 Jan 16; 130(2):436-7.
View on PubMed
Dwell time analysis of a single-molecule mechanochemical reaction. Szoszkiewicz R, Ainavarapu SR, Wiita AP, Perez-Jimenez R, Sanchez-Ruiz JM, Fernandez JM. Langmuir. 2008 Feb 19; 24(4):1356-64.
View on PubMed
Probing the chemistry of thioredoxin catalysis with force. Wiita AP, Perez-Jimenez R, Walther KA, Gräter F, Berne BJ, Holmgren A, Sanchez-Ruiz JM, Fernandez JM Nature. 2007 Nov 1; 450(7166):124-7.
View on PubMed
Contour length and refolding rate of a small protein controlled by engineered disulfide bonds. Ainavarapu SR, Brujic J, Huang HH, Wiita AP, Lu H, Li L, Walther KA, Carrion-Vazquez M, Li H, Fernandez JM. Biophys J. 2007 Jan 1; 92(1):225-33.
View on PubMed
Force-dependent chemical kinetics of disulfide bond reduction observed with single-molecule techniques. Wiita AP, Ainavarapu SR, Huang HH, Fernandez JM. Proc Natl Acad Sci U S A. 2006 May 9; 103(19):7222-7.
View on PubMed
Molecular targeting of inhibitor of apoptosis proteins based on small molecule mimics of natural binding partners. Kipp RA, Case MA, Wist AD, Cresson CM, Carrell M, Griner E, Wiita A, Albiniak PA, Chai J, Shi Y, Semmelhack MF, McLendon GL. Biochemistry. 2002 Jun 11; 41(23):7344-9.
View on PubMed